Pharmacological Evaluation of Saccharum Officinarum Linn. as Anti-ulcer Agent

Abstract

The purpose of the study was to elucidate the antiulcer activity of
stem of Saccharum Officinarum (Poaceae) in albino rats against
aspirin induced gastric ulcer, ethanol induced gastric ulcer and
pylorus ligation induced gastric ulcer models. Groups of rats were
fasted overnight, received ranitidine (20 mg/kg) as a standard and
plant stem juice extract at dose of 0.75 mL/100 gm and 1.5 mL/100
gm as a treatment against aspirin induced gastric ulcer, ethanol
induced gastric ulcer and pylorus ligation induced gastric ulcer.
The treatment produced significant protection of ulcer induced by
aspirin, ethanol and pylorus ligation induced ulcer. The extract also
reduced ulcer index, volume of gastric content, free and total acidity,
suggesting that extract possesses significant anti-ulcer activity.