Physalis peruviana oil based NLCs for dermal drug delivery

Abstract

Nanostructured lipid carriers (NLC) are a new progression in the area
of lipid nanoparticles which are preferred for topical use. NLC possess
reasonable solubility enhancement capacity of poorly soluble drugs,
which create a high concentration gradient to aid the permeation of
drug. The endeavor of this study was to develop and analyze Physalis
peruvianaoil based NLC. Theoilwas extracted by hot soxhlation
using n-hexane as the solvent and the extracted oil wasutilized as
an excipient (liquid lipid). Factorial design was adopted to optimize
the amount of lipid blend (extracted oil and solid lipid), surfactant
(Pluronic F-68) and sonication time to formulate NLC. The optimized
formulations of fluconazole loaded NLC (PP-F-NLC) were evaluated
by particle size, antifungal study, occlusion test, in-vitro skin permeation
study and irritation test on animal skin. EE was found to be
99.96% and the optimized formulation showed 83% drug release in
24 hours. The formulated NLC showed better skin penetration, and
potent antifungal activity against Microsporum fulvum as compared
to marketed gel.It was concluded that the Physalis peruviana oil
incorporated NLC is a promising formulation for fungal treatment
and possesses high antioxidant potency.Physalis peruviana NLC can
act as a potential carrier for anti-fungal/anti-inflammatory drugs
to enhancethe purported pharmacological activity against various
problems.