Cosmoceutical and Therapeutic Potential of Isotretinoin Nanoparticulate Gel in Management of Acne

Abstract

This study intended to develop and evaluate isotretinoin (ITR)
loaded nanoparticles taking chitosan as a polymer of interest. Ionic
crosslinking method was utilized to prepare nanoparticles. Nanoparticles
were formulated using varying ratios (chitosan: tripolyphosphate)
and evaluated for its size, distribution of size, zeta potential,
percentage of ITR entrapped within nanoparticles, in vitro drug
release and its stability under accelerated conditions. The prepared
nanoparticles (NPs) were spherical, white in color and free flowing,
321± 4.5 nm was the average size of optimized chitosan nanoparticles
and it was able to entrap 88.76 ± 3.5%. The outcomes assured
vast promise of the CNs of ITR (optimized) in management of acne
and also increasing the therapeutic efficacy, thus establish to be a
promising, effective and patient compliant formulation.